Istanbul to Cappadocia 730 km. You can travel to Cappadocia by bus or by plane. Bus trip takes about 10 hour and mostly buses are running at nights, it is overnight buses. A few different bus company arrange daily departure to Cappadocia. These companies are; Nevsehir Seyehat, Metro turizim and Suha. Buses are quite nice but not so much comfortable, no sleeping seat.
The second option is plane. Istanbul to Cappadocia a few different company flying everyday and it takes 1 hour 10 minutes.
We highly suggest to join Cappadocia tour from Istanbul which will be more comfortable.